Description

Hptu CAS NO 364047-51-8 is a high-purity chemical intermediate, specifically a peptide coupling reagent, essential for modern synthetic organic chemistry. Its primary value lies in its efficiency and selectivity in facilitating amide bond formation, a critical step in the synthesis of complex molecules. This product is indispensable for research and production teams in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable and high-yielding reagents for peptide and active pharmaceutical ingredient (API) synthesis.

Application

• Peptide Synthesis: As a coupling reagent for the efficient formation of amide bonds in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) requiring precise amide linkages.
• Bioconjugation: Facilitates the labeling and conjugation of peptides, proteins, and other biomolecules with tags, dyes, or drug payloads.
• Combinatorial Chemistry: A key reagent in library synthesis for drug discovery and high-throughput screening applications.
• Academic & Industrial R&D: Employed in research laboratories for the development of new synthetic methodologies and novel compounds.
• Specialty Chemical Production: Used in the manufacture of specialty polymers, dendrimers, and other advanced materials where controlled amide bond formation is required.

Basic Information

Product Name	Hptu
CAS No.	364047-51-8
Molecular Formula	C₁₀H₁₅F₆N₆OP
Molecular Weight	380.23 g/mol
Synonyms	HPTU; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate; (1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, 3-oxide, hexafluorophosphate(1-)); Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium; O-(1H-1,2,3-Triazolo[4,5-b]pyridin-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; Coupling Reagent HPTU
EINECS	Contact for details

Quality Control

Our Hptu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in polar aprotic solvents (DMF, DMSO, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.