Description

H2N-PEG12-CH2CH2NH2 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at each terminus. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the creation of stable, hydrophilic linkers for drug delivery systems, diagnostics, and advanced materials. It is essential for researchers and manufacturers in the biopharmaceutical, nanotechnology, and life sciences sectors who require precise and reliable PEGylation reagents to enhance the solubility, stability, and pharmacokinetics of their therapeutic agents.

Application

• As a versatile linker for the PEGylation of proteins, peptides, and antibodies to improve therapeutic properties.
• In the synthesis of drug conjugates and antibody-drug conjugates (ADCs) for targeted cancer therapies.
• For surface functionalization and modification of nanoparticles, liposomes, and other drug delivery carriers.
• As a spacer arm in the development of biosensors, diagnostic assays, and microarray platforms.
• In materials science for creating hydrogel networks, smart polymers, and biocompatible coatings.
• For crosslinking applications in the preparation of protein-polymer hybrids and biomaterials.

Basic Information

Product Name	H2N-PEG12-CH2CH2NH2
CAS No.	361543-12-6
Molecular Formula	C28H60N2O13
Molecular Weight	632.8 g/mol
Synonyms	α,ω-Bis(2-aminoethyl)poly(oxy-1,2-ethanediyl); 1,2-Ethanediamine, N1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-N2-(2-aminoethyl)-; Bis(2-aminoethyl) PEG12; Amine-PEG12-amine; NH2-PEG12-NH2; 4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxanonatriacontane-1,39-diamine; PEG 600 diamine
EINECS	Contact for details

Quality Control

Our H2N-PEG12-CH2CH2NH2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and GMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool environment. Due to its hygroscopic and easily oxidized nature, allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Titration)	≥ 90%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	Within ± 5 Da of theoretical
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.