Description

n-Azidoacetylmannosamine-Tetraacylated is a chemically modified monosaccharide derivative, specifically a peracetylated mannosamine bearing an azidoacetyl group at the N-position. This compound is a critical intermediate and metabolic precursor in chemical biology and glycobiology research, enabling the bioorthogonal labeling and study of cell-surface glycans. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications such as metabolic oligosaccharide engineering, glycan imaging, and the development of novel glycoconjugate therapeutics and vaccines.

Application

• Metabolic Glycan Engineering (MGE): Serves as a metabolic precursor for the incorporation of azide-tagged sialic acids into cell-surface glycoconjugates for subsequent bioorthogonal labeling (e.g., via click chemistry).
• Glycobiology Research: A key tool for studying sialylation pathways, glycan trafficking, and the functional roles of sialic acids in cellular communication and disease.
• Fluorescent Cell Imaging: Enables the visualization and tracking of newly synthesized glycans on live cells through reaction with fluorescent probes bearing complementary functional groups (e.g., dibenzocyclooctyne, DBCO).
• Drug Discovery & Development: Used in the synthesis and screening of sialyltransferase inhibitors and the development of glycan-based vaccines and targeted therapeutics.
• Diagnostic Probe Development: Facilitates the creation of diagnostic tools for detecting specific glycan biomarkers associated with cancer, inflammation, and infectious diseases.
• Material Science & Bioconjugation: Employed to functionalize surfaces, nanoparticles, or polymers with bioactive sugars for creating advanced biomaterials and biosensors.

Basic Information

Product Name	n-Azidoacetylmannosamine-Tetraacylated
CAS No.	361154-30-5
Molecular Formula	C16H22N4O10
Molecular Weight	430.37 g/mol
Synonyms	ManNAz tetraacetate; N-Azidoacetyl-D-mannosamine tetraacetate; Peracetylated N-azidoacetylmannosamine; Ac4ManNAz; 2-Acetamido-2-deoxy-1,3,4,6-tetra-O-acetyl-α/β-D-mannopyranose with N-azidoacetyl modification; D-Mannosamine, N-(azidoacetyl)-, tetraacetate; Metabolic precursor for azido-sialic acid
EINECS	Contact for details

Quality Control

Our n-Azidoacetylmannosamine-Tetraacylated is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research or cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.