Description

11-Maleimidoundecanoic Acid Hydrazide is a heterobifunctional crosslinking agent featuring a maleimide group and a hydrazide moiety separated by a long alkyl spacer. This compound is engineered for the site-specific conjugation of biomolecules, offering controlled reactivity and enhanced stability in bioconjugation workflows. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced materials science for creating stable protein-drug conjugates, antibody-oligonucleotide hybrids, and functionalized surfaces.

Application

• Bioconjugation Reagent: For the site-specific coupling of peptides, proteins, or antibodies to other molecules (e.g., drugs, dyes, polymers, surfaces) via its maleimide-thiol and hydrazide-aldehyde/ketone chemistry.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical component in the synthesis of next-generation ADCs, connecting cytotoxic payloads to monoclonal antibodies with a stable, cleavable, or non-cleavable linkage.
• Diagnostic Probe Synthesis: Used to label antibodies, enzymes, or other proteins with fluorescent dyes, enzymes, or haptens for use in ELISA, lateral flow assays, and immunohistochemistry.
• Surface Functionalization: Enables the covalent attachment of biomolecules to nanoparticles, microarrays, biosensor chips, and other solid supports for creating bioactive interfaces.
• Polymer Modification: Incorporates reactive handles into hydrogels, dendrimers, or other polymeric materials to create smart drug delivery systems or tissue engineering scaffolds.
• Protein Immobilization: Facilitates the oriented and stable immobilization of enzymes or other proteins for biocatalysis and affinity purification applications.

Basic Information

Product Name	11-Maleimidoundecanoic Acid Hydrazide
CAS No.	359436-62-7
Molecular Formula	C15H23N3O4
Molecular Weight	309.36 g/mol
Synonyms	11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic hydrazide; N-(11-Hydrazinyl-11-oxoundecyl)maleimide; Maleimidoundecanoic hydrazide; 1H-Pyrrole-1-undecanoic acid, 2,5-dihydro-2,5-dioxo-, hydrazide; Heterobifunctional crosslinker, Maleimide-Hydrazide, C11 spacer
EINECS	Contact for details

Quality Control

Our 11-Maleimidoundecanoic Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional group titration to ensure consistent performance as a crosslinking agent. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. For long-term storage, desiccate to minimize moisture uptake. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.