Description

3-Maleimidopropionic Acid Hydrazonium, Trifluoroacetate is a high-purity, heterobifunctional crosslinking reagent featuring a maleimide group and a hydrazide moiety. This compound is critical for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined constructs for advanced research and development. It is primarily utilized by researchers and process developers in the pharmaceutical, bioconjugation, and diagnostics industries for antibody-drug conjugate (ADC) development, protein labeling, and surface immobilization.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable, or non-cleavable linkers connecting cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: For site-specific labeling of cysteine-containing proteins or peptides via the maleimide group, followed by conjugation of aldehydes or ketones via the hydrazide function.
• Bioconjugation Reagent: Enables the crosslinking of different biomolecules (e.g., enzymes, antibodies, oligonucleotides) to create novel diagnostic or therapeutic agents.
• Surface Functionalization: Used to modify sensor chips, nanoparticles, or chromatographic supports with reactive groups for biomolecule capture and analysis.
• Polymer Chemistry: Serves as a functional monomer or crosslinker in the synthesis of smart polymers and hydrogels with tailored biological activity.
• Carbohydrate Labeling: Conjugation reagent for tagging oxidized glycans or glycoproteins in glycomics and glycoproteomics research.

Basic Information

Product Name	3-Maleimidopropionic Acid Hydrazonium, Trifluoroacetate
CAS No.	359436-61-6
Molecular Formula	C8H10F3N3O5
Molecular Weight	285.18 g/mol
Synonyms	3-Maleimidopropionic Acid Hydrazide Trifluoroacetate Salt; 3-Maleimidopropionic Hydrazide TFA Salt; Maleimidopropionic Acid Hydrazide TFA; 3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)propanehydrazonic Acid Trifluoroacetate; MPH-TFA; 1-(3-Hydrazinyl-3-oxopropyl)-1H-pyrrole-2,5-dione Trifluoroacetate; β-Maleimidopropionic Acid Hydrazide Trifluoroacetate; BMPH-TFA
EINECS	Contact for details

Quality Control

Our 3-Maleimidopropionic Acid Hydrazonium, Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for bioconjugation and pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.