Description

1,6-Hexane-Bis-[3-(2-Pyridyldithio)Propionamide] is a specialized heterobifunctional crosslinking agent featuring a cleavable disulfide bond and reactive pyridyldithio groups. This compound is critical for creating stable yet reversible linkages, primarily in advanced bioconjugation and protein modification workflows. It is essential for researchers and manufacturers in the fields of biopharmaceutical development, antibody-drug conjugate (ADC) synthesis, and advanced materials science who require precise control over molecular assembly.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key reagent for constructing cleavable linkers between monoclonal antibodies and cytotoxic payloads, leveraging its disulfide bridge for controlled drug release in targeted cancer therapies.
• Protein-Protein Crosslinking: Used to study protein interactions, stabilize protein complexes, or create protein-based materials through the formation of reversible disulfide bonds.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, or chromatographic media with thiol-reactive groups for subsequent conjugation with biomolecules.
• Polymer Chemistry: Serves as a chain extender or crosslinker in the synthesis of smart polymers and hydrogels that respond to reducing environments.
• Bioconjugation Reagent: Facilitates the attachment of peptides, drugs, or labels to proteins, antibodies, or other carriers under mild conditions.
• Prodrug Development: Utilized in the design of prodrug systems where the active agent is released upon exposure to intracellular reducing conditions like glutathione.

Basic Information

Product Name	1,6-Hexane-Bis-[3-(2-Pyridyldithio)Propionamide]
CAS No.	359435-46-4
Molecular Formula	C24H32N4O2S4
Molecular Weight	552.80 g/mol
Synonyms	N,N'-Hexane-1,6-diylbis[3-(2-pyridyldithio)propanamide]; 1,6-Bis[3-(2-pyridyldithio)propionamido]hexane; PDPH; Heterobifunctional PDPH Crosslinker; 2,2'-Dithiodipyridine-based crosslinker; SPDP Homobifunctional Analog; DTBP Crosslinking Agent; Hexane PDP Crosslinker
EINECS	Contact for details

Quality Control

Our 1,6-Hexane-Bis-[3-(2-Pyridyldithio)Propionamide] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic and light-sensitive nature, the container should be equilibrated to room temperature before opening to minimize moisture uptake. Keep under an inert atmosphere for long-term storage to preserve stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.