Description

Ac-Asp-Met-Gln-Asp-Amc CAS NO 355137-38-1 is a synthetic peptide derivative, specifically a fluorogenic substrate designed for protease activity assays. This compound is of significant value in biochemical research and pharmaceutical development for its role in detecting and quantifying specific enzymatic activity. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in protease inhibitor screening and enzyme mechanism studies.

Application

• Protease Research & Assay Development: As a fluorogenic substrate for studying the kinetics and specificity of caspases and related proteases.
• High-Throughput Screening (HTS): Used in automated platforms for the discovery and validation of novel protease inhibitors as potential drug candidates.
• Apoptosis (Programmed Cell Death) Studies: A critical tool for monitoring caspase activity, a key indicator of apoptotic pathways in cellular models.
• Diagnostic Reagent Formulation: Incorporated into kits for the detection of specific protease activities associated with diseases.
• Biochemical Pathway Analysis: Employed to elucidate the role of specific proteolytic events in signal transduction and other cellular processes.
• Quality Control in Biologics: Used to assess the presence and activity of process-related proteases in biomanufacturing.

Basic Information

Product Name	Ac-Asp-Met-Gln-Asp-Amc
CAS No.	355137-38-1
Molecular Formula	C28H38N6O12S
Molecular Weight	658.70 g/mol
Synonyms	Ac-DMQD-AFC (Alternative fluorophore); Ac-DMQD-AMC; Ac-Asp-Met-Gln-Asp-7-Amino-4-methylcoumarin; Ac-DMQD-AMC; Caspase Substrate; N-Acetyl-Asp-Met-Gln-Asp-AMC; Fluorogenic Caspase-3 Substrate; Ac-DEVD-AMC Analog
EINECS	Contact for details

Quality Control

Our Ac-Asp-Met-Gln-Asp-Amc is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the high standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.