Description

α-Cyano-4-Hydroxycinnamic Acid Dieth is a specialized cinnamic acid derivative, primarily recognized as a high-performance matrix compound for Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry. Its core value lies in its exceptional ability to facilitate the ionization of peptides, proteins, and other biomolecules with high sensitivity and low background noise, enabling precise analytical results. This product is essential for research and quality control laboratories in the pharmaceutical, proteomics, and life sciences sectors, where accurate molecular weight determination and structural analysis are critical.

Application

• MALDI-TOF Mass Spectrometry Matrix: The primary application is as a matrix for analyzing peptides, proteins, oligonucleotides, and synthetic polymers.
• Proteomics and Biomarker Discovery: Used in high-throughput protein profiling and identification workflows.
• Pharmaceutical QC and Impurity Analysis: Employed for the characterization of biopharmaceuticals and the detection of low-level impurities.
• Clinical Diagnostics: Supports mass spectrometry-based diagnostic assays for disease detection.
• Organic Synthesis Intermediate: Serves as a building block for synthesizing more complex cinnamic acid derivatives with potential biological activity.
• Material Science Research: Investigated for its photophysical properties in the development of organic electronic materials.

Basic Information

Product Name	α-Cyano-4-Hydroxycinnamic Acid Dieth
CAS No.	355011-52-8
Molecular Formula	C14H15NO4
Molecular Weight	261.27 g/mol
Synonyms	4-Hydroxy-α-cyano-cinnamic acid diethyl acetal; CHCA Diethyl Acetal; α-Cyano-4-hydroxycinnamic acid diethyl acetal; MALDI Matrix CHCA Diethyl Acetal; 3-(4-Hydroxyphenyl)-2-cyanoacrylic acid diethyl acetal; Diethyl (2-cyano-3-(4-hydroxyphenyl)allyl) ether; (E)-2-Cyano-3-(4-hydroxyphenyl)acrylic acid diethyl acetal
EINECS	Contact for details

Quality Control

Our α-Cyano-4-Hydroxycinnamic Acid Dieth is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
MALDI Performance	Tested for optimal ionization of standard peptides

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.