Description

6-(Biotinylamino)Thiocaproic Acid, S-Ethyl Ester is a specialized biotin derivative featuring a cleavable thioester linkage. This compound is engineered to provide a versatile platform for the site-specific biotinylation of biomolecules, enabling downstream purification or detection. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications in proteomics, diagnostics, and targeted drug delivery systems.

Application

• Bioconjugation Reagent: For the controlled, covalent attachment of biotin tags to proteins, peptides, and antibodies via thiol-reactive chemistry.
• Affinity Chromatography Ligand Synthesis: Used to functionalize solid supports (e.g., agarose beads) for the purification of streptavidin/avidin-binding complexes.
• Diagnostic Assay Development: Serves as a key intermediate in creating biotinylated probes for ELISA, lateral flow assays, and other immunoassay formats.
• Proteomic Research: Enables labeling and isolation of specific protein targets or complexes for mass spectrometric analysis.
• Drug Delivery Systems: Facilitates the development of biotin-drug conjugates for targeted therapies utilizing the high-affinity biotin-streptavidin interaction.
• Surface Modification: Employed to create biotinylated surfaces for biosensor development and microarray technologies.

Basic Information

Product Name	6-(Biotinylamino)Thiocaproic Acid, S-Ethyl Ester
CAS No.	353754-94-6
Molecular Formula	C18H31N3O3S2
Molecular Weight	401.58 g/mol
Synonyms	Biotin-6-amidohexyl-3'-thiopropionate S-ethyl ester; S-Ethyl 6-[(5-{3aS,4S,6aR}-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido]hexylthio]propanethioate; Biotin-HPDP-SE; Biotinylated Alkyl Thioester; N-Biotinyl-6-aminohexyl-3'-thiopropionate S-ethyl ester; EZ-Link Biotin-HPDP; Biotin labeling reagent (thioester).
EINECS	Contact for details

Quality Control

Our 6-(Biotinylamino)Thiocaproic Acid, S-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.