Description

Sodium 17Beta-Dihydroequilin-2,4,16,16-D4 3-Sulfate is a high-purity, deuterium-labeled sodium salt of a conjugated equine estrogen derivative. This compound is of critical importance for use as a certified reference standard in analytical chemistry, enabling precise quantification and method validation in complex matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities focused on bioanalytical studies, pharmacokinetics, and quality control of hormone-based therapeutics.

Application

• Certified Reference Material (CRM) for the calibration of analytical instruments (e.g., LC-MS/MS, HPLC).
• Internal Standard in quantitative bioanalysis for drug metabolism and pharmacokinetic (DMPK) studies.
• Method Development and Validation for the assay of estrogenic compounds in pharmaceutical formulations and biological samples.
• Quality Control testing in the manufacturing of steroid-based active pharmaceutical ingredients (APIs).
• Stability-Indicating Assays to monitor the degradation profiles of related steroid products.
• Research Use in endocrinology and metabolic studies investigating estrogen pathways.

Basic Information

Product Name	Sodium 17Beta-Dihydroequilin-2,4,16,16-D4 3-Sulfate
CAS No.	352431-51-7
Molecular Formula	C18H18D4NaO5S
Molecular Weight	Contact for details
Synonyms	17β-Dihydroequilin-2,4,16,16-d4 3-Sulfate Sodium Salt; Sodium 17β-Dihydroequilin-d4 Sulfate; [2,4,16,16-2H4]-17β-Dihydroequilin 3-Sulfate Sodium Salt; Deuterated Sodium Equilenin Sulfate; D4-Labeled Equilin Sulfate Sodium Salt; (13S,17β)-13-Methyl-2,4,16,16-tetradeuterio-6,7,8,13,14,15,16,17-octahydro-3H-cyclopenta[a]phenanthrene-3,17-diol 3-Sulfate Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Sodium 17Beta-Dihydroequilin-2,4,16,16-D4 3-Sulfate is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for reference materials, including assessment of chemical purity, isotopic enrichment, and solution stability. Certificates of Analysis (COA) are available upon request, providing full traceability and detailed analytical results from techniques such as NMR, HPLC, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.