Description

Sodium 17Beta-Estradiol-2,4,16,16-D4 3-Sulfate is a deuterium-labeled sodium salt of estradiol sulfate, a key metabolite of the primary female sex hormone. This high-purity, isotopically labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in hormone level measurement. It is critically needed by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers specializing in hormone replacement therapy, endocrinology studies, and mass spectrometry-based assays.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the precise measurement of endogenous estradiol sulfate levels in biological matrices (plasma, serum, urine).
• Clinical Research & Diagnostics: Enables accurate hormone profiling in studies related to menopause, osteoporosis, fertility, endocrine disorders, and hormone-dependent cancers.
• Pharmaceutical Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies during the development of hormone-based therapeutics to track metabolite formation and clearance.
• Forensic & Anti-Doping Analysis: Supports sensitive detection methods for monitoring steroid hormone abuse in sports and forensic toxicology.
• Metabolite Reference Standard: Serves as a certified reference material for the identification and quantification of the sulfated metabolite of estradiol in complex samples.
• Method Development & Validation: Critical for developing, validating, and ensuring the regulatory compliance (FDA, EMA) of bioanalytical assays in GLP/GCP environments.

Basic Information

Item	Detail
Product Name	Sodium 17Beta-Estradiol-2,4,16,16-D4 3-Sulfate
CAS No.	352431-50-6
Molecular Formula	C18H19D4NaO5S
Molecular Weight	378.45 g/mol (approx.)
Synonyms	Estradiol-2,4,16,16-d4 3-Sulfate Sodium Salt; Sodium Estradiol-d4 Sulfate; [2,4,16,16-2H4]-Estradiol 3-Sulfate Sodium Salt; 17β-Estradiol-2,4,16,16-d4 3-(Sodium Sulfate); Deuterated Estradiol Sulfate Sodium Salt; E2-d4 Sulfate Sodium; 1,3,5(10)-Estratrien-3,17β-diol-2,4,16,16-d4 3-Sulfate Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of our Sodium 17Beta-Estradiol-2,4,16,16-D4 3-Sulfate is manufactured and controlled under strict quality management systems. The product undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm chemical identity, isotopic purity (deuterium enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment supports compliance with the standards required for GMP, GLP, and ISO 17034 for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.