Description

Figopitant is a high-purity, non-peptide neurokinin 1 (NK1) receptor antagonist. This compound is a critical pharmaceutical intermediate and reference standard for the development of antiemetic medications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutics for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced antiemetic drug candidates targeting the NK1 receptor.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical R&D and manufacturing.
• Biochemical Research: A vital tool for in vitro and in vivo studies investigating the role of substance P and NK1 receptor pathways.
• Preclinical Development: Serves as a lead compound or comparator in pharmacokinetic, pharmacodynamic, and toxicology studies.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of related therapeutic agents.

Basic Information

Item	Details
Product Name	Figopitant
CAS No.	350610-25-2
Molecular Formula	C22H24FN3O2
Molecular Weight	381.45 g/mol
Synonyms	Figopitant; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; GW679769; Casopitant metabolite M1; NK1 Receptor Antagonist (Figopitant); (R)-5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1,2-dihydro-3H-1,2,4-triazol-3-one
EINECS	Contact for details

Quality Control

Our Figopitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.