Description

4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol-n-B-D-Glucuronide is a key metabolite of the tobacco-specific nitrosamine NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone), making it a critical biomarker for assessing human exposure to tobacco carcinogens. Its high purity and stability are essential for accurate analytical quantification in complex biological matrices. This compound is primarily required by research institutions, clinical laboratories, and pharmaceutical companies engaged in toxicology studies, biomarker validation, and cancer research.

Application

• Biomarker Reference Standard for quantifying NNK exposure in human urine, serum, and other biological samples in epidemiological studies.
• Internal Standard in LC-MS/MS and HPLC analyses, ensuring precision and accuracy in method development and validation for tobacco-related research.
• Toxicology and Metabolic Pathway Studies to investigate the detoxification and bioactivation mechanisms of tobacco-specific nitrosamines.
• Calibration Standard for clinical diagnostic assays and kits designed to measure tobacco smoke exposure and associated health risks.
• Pharmaceutical Research for studying chemoprevention agents aimed at inhibiting the metabolic activation of procarcinogens like NNK.
• Regulatory and Compliance Testing supporting studies for public health agencies and product safety evaluations.

Basic Information

Product Name	4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol-n-B-D-Glucuronide
CAS No.	350508-29-1
Molecular Formula	C₁₆H₂₃N₃O₈
Molecular Weight	385.37 g/mol
Synonyms	NNAL-Glucuronide; NNAL-O-Glucuronide; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide; NNAL Gluc; (R,S)-NNAL-N-glucuronide; NNAL-N-Gluc; 1-(3-Pyridyl)-1-butanol-4-(methylnitrosamino) β-D-glucopyranosiduronic acid; Tobacco-specific nitrosamine metabolite
EINECS	Contact for details

Quality Control

Every batch of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol-n-B-D-Glucuronide is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high purity and batch-to-batch consistency suitable for sensitive analytical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.