Description

3α,7α,12α-Trihydroxycoprostanic Acid-D3 is a deuterium-labeled analog of a key bile acid intermediate, offering a stable isotopic tracer for advanced metabolic and biochemical research. This high-purity compound is essential for precise quantification and pathway elucidation in studies of cholesterol metabolism and bile acid synthesis. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers focused on hepatology and lipid disorders.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of endogenous bile acids in complex biological matrices like serum, plasma, and urine.
• Metabolic Pathway Tracing: Used in stable isotope dilution studies to investigate the biosynthesis, turnover, and metabolic fate of bile acids in vitro and in vivo.
• Pharmaceutical Development: Supports drug discovery and development programs targeting bile acid receptors, cholestatic liver diseases, and metabolic disorders.
• Clinical Diagnostics Research: Enables the development and validation of high-sensitivity assays for diagnosing inborn errors of bile acid metabolism.
• Biochemical Research: A valuable tool for enzymology studies, particularly for enzymes involved in the sterol and bile acid synthesis pathways.

Basic Information

Product Name	3α,7α,12α-Trihydroxycoprostanic Acid-D3
CAS No.	338976-79-7
Molecular Formula	C27H43D3O5
Molecular Weight	453.66 g/mol (approx.)
Synonyms	3α,7α,12α-Trihydroxy-5β-cholestan-26-oic-26,26,26-d3 Acid; (25R)-3α,7α,12α-Trihydroxy-5β-cholestan-26-oic-26,26,26-d3 Acid; Trihydroxycoprostanic Acid-d3; Deuterated Trihydroxycoprostanic Acid; 5β-Cholestan-26-oic-26,26,26-d3 acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α,25R)-; THCA-d3
EINECS	Contact for details

Quality Control

Our 3α,7α,12α-Trihydroxycoprostanic Acid-D3 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and purity by HPLC. We adhere to cGMP principles for research chemicals, ensuring traceability and consistency for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.