Description

L(+)-2-Amino-6-Phosphonohexanoic Acid Hydrate is a high-purity, chiral amino acid derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a potent and selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), making it a critical tool for neurological studies. It is primarily utilized by research institutions and pharmaceutical developers focused on neuroscience, neuropharmacology, and the development of treatments for neurological disorders. Its defined stereochemistry and phosphonate group are essential for its specific biological activity and receptor binding affinity.

Application

• Neuroscience Research: As a selective mGluR5 antagonist for investigating glutamatergic signaling pathways, synaptic plasticity, and neuronal excitability.
• Neuropharmacology: A key reference standard and pharmacological tool in the study and development of potential therapeutics for conditions like anxiety, depression, Fragile X syndrome, and Parkinson's disease.
• Biochemical Assay Development: Used in high-throughput screening (HTS) and in vitro binding assays to identify and characterize new modulators of mGluR5 activity.
• Academic & Institutional Research: Employed in university and government labs for fundamental research into the role of group I metabotropic glutamate receptors in the central nervous system.
• Preclinical Drug Discovery: Serves as a benchmark compound for evaluating the efficacy and specificity of novel drug candidates targeting mGluR5.

Basic Information

Product Name	L(+)-2-Amino-6-Phosphonohexanoic Acid Hydrate
CAS No.	335150-85-1
Molecular Formula	C6H14NO6P · xH2O
Molecular Weight	227.15 g/mol (Anhydrous basis)
Synonyms	L-2-Amino-6-phosphonohexanoic Acid Hydrate; (S)-2-Amino-6-phosphonohexanoic Acid Hydrate; L-AP6; L-2-Amino-6-phosphonocaproic Acid; L-AP6 Hydrate; (S)-AP6; LY 367385 (Isomer); mGluR5 Antagonist LY367385 (Isomer); (S)-2-Amino-6-phosphonohexanoic acid monohydrate
EINECS	Contact for details

Quality Control

Our L(+)-2-Amino-6-Phosphonohexanoic Acid Hydrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0% (on anhydrous basis)
Optical Rotation	Specific range provided on COA
Water Content (KF)	As per hydrate form
Heavy Metals	<20 ppm
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.