Description

n-Dihydrocinnamoylaminocaproic Acid, n-Hydroxysuccinimide Ester is a high-purity, activated ester derivative primarily used as a versatile bioconjugation and crosslinking reagent. This compound matters for its ability to facilitate efficient and selective coupling reactions, particularly for modifying proteins, peptides, and other amine-containing biomolecules under mild aqueous conditions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable and high-quality intermediates for drug discovery, diagnostic assay development, and biomaterial synthesis.

Application

• Bioconjugation Reagent: For the covalent attachment of dihydrocinnamoyl ligands, peptides, or other molecules to proteins, antibodies, or nanoparticles via primary amine groups (lysine residues).
• Crosslinking Agent: Used in the preparation of immunoconjugates, antibody-drug conjugates (ADCs), and other macromolecular assemblies.
• Proteomics Research: As a tool for labeling, immobilizing, or modifying proteins and peptides in mass spectrometry and other analytical workflows.
• Diagnostic Kit Manufacturing: In the production of enzyme-linked immunosorbent assays (ELISA) and other diagnostic reagents requiring stable protein conjugates.
• Biomaterial Functionalization: For introducing specific chemical functionalities onto polymer surfaces, hydrogels, or medical devices to enhance biocompatibility or enable drug delivery.
• Intermediate in Organic Synthesis: Serves as a key building block for the synthesis of more complex pharmaceutical compounds and specialized biochemical probes.

Basic Information

Product Name	n-Dihydrocinnamoylaminocaproic Acid, n-Hydroxysuccinimide Ester
CAS No.	334616-48-7
Molecular Formula	C19H24N2O5
Molecular Weight	360.41 g/mol
Synonyms	NHS-Dihydrocinnamoyl-6-Aminocaproate; 6-[(3-Phenylpropanoyl)amino]hexanoic Acid N-Hydroxysuccinimide Ester; Dihydrocinnamoyl-6-Aminocaproic Acid NHS Ester; N-Succinimidyl 6-(3-Phenylpropanamido)hexanoate; 3-Phenylpropionyl-ε-aminocaproic Acid N-Hydroxysuccinimide Ester; N-Hydroxysuccinimide Ester of Dihydrocinnamoyl-6-Aminocaproic Acid; NHS-Activated Dihydrocinnamoyl Caproate; DHC-C6-NHS Ester
EINECS	Contact for details

Quality Control

Our n-Dihydrocinnamoylaminocaproic Acid, n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and consistent performance as a bioconjugation reagent. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis of the active NHS ester. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.