Description

Vestipitant Mesylate is a high-purity, non-peptide neurokinin-1 (NK1) receptor antagonist. This compound is of significant interest for its potential role in modulating central nervous system pathways related to stress, anxiety, and emesis. It is primarily utilized by pharmaceutical research and development organizations engaged in preclinical studies and the development of novel therapeutic agents targeting the NK1 receptor.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in drug substance and product testing.
• Preclinical Research: Used in in vitro and in vivo studies to investigate the pharmacological profile and efficacy of NK1 receptor antagonism.
• Mechanistic Studies: A key tool compound for exploring the role of substance P and the NK1 receptor in neurological and psychiatric conditions.
• Drug Discovery & Development: Employed as a building block or intermediate in the synthesis and optimization of new chemical entities targeting neurokinin pathways.
• Academic Research: Utilized in university and institutional labs for fundamental neuroscience and pharmacology research.

Basic Information

Product Name	Vestipitant Mesylate
CAS No.	334476-64-1
Molecular Formula	C28H37N5O5S
Molecular Weight	555.69 g/mol
Synonyms	GW597599; Vestipitant Methanesulfonate; 2-[4-(5-Chloro-2-methoxyphenyl)piperazin-1-yl]-N-(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3-methylbenzamide methanesulfonate; (2R)-2-[4-(5-Chloro-2-methoxyphenyl)piperazin-1-yl]-N-[(3,5-dimethylisoxazol-4-yl)methyl]-3-methylbenzamide methanesulfonate
EINECS	Contact for details

Quality Control

Every batch of Vestipitant Mesylate CAS NO 334476-64-1 is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.