Description

Vestipitant CAS NO 334476-46-9 is a potent and selective neurokinin-1 (NK1) receptor antagonist. This compound is a critical research tool and pharmaceutical intermediate for investigating and developing treatments for central nervous system disorders. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions focused on neuroscience, psychiatry, and drug discovery.

Application

• Pharmaceutical Research & Development: A key reference standard and intermediate in the development of novel therapeutics targeting the NK1 receptor pathway.
• Neuroscience Studies: Used in preclinical research to study the role of substance P and NK1 receptors in conditions like anxiety, depression, and emesis.
• Reference Standard for Analytical Testing: Serves as a high-purity standard for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.
• Biochemical Assay Development: Employed in vitro for screening and characterizing new NK1 receptor antagonist candidates.
• Academic Research: Supports fundamental research in neuropharmacology and behavioral science at universities and research institutes.
• GMP Intermediate Production: Supplied as a starting material or intermediate for the synthesis of active pharmaceutical ingredients (APIs) under controlled conditions.

Basic Information

Product Name	Vestipitant
CAS No.	334476-46-9
Molecular Formula	C23H30FN3O3
Molecular Weight	415.51 g/mol
Synonyms	GW597599; GW-597599; 2-[(3,5-Bis(trifluoromethyl)benzyl)oxy]-4-(4-fluorophenyl)-6-[(2S)-2-phenyl-1-pyrrolidinyl]-3-pyridinecarboxamide; 4-(4-Fluorophenyl)-2-({[3,5-bis(trifluoromethyl)phenyl]methyl}oxy)-6-[(2S)-2-phenyl-1-pyrrolidinyl]pyridine-3-carboxamide; Vestipitant (GW597599)
EINECS	Contact for details

Quality Control

Our Vestipitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.