Description

Rac N,o-Didesmethyl Tramadol CAS NO 333364-41-3 is a key intermediate and reference standard in pharmaceutical research and development. This compound is of significant importance for analytical and metabolic studies related to the opioid analgesic tramadol. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for use in method development, quality control, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of tramadol and its metabolites in analytical testing.
• Metabolite Research: Serves as a critical standard in pharmacokinetic and metabolic pathway studies to understand the biotransformation of tramadol.
• Impurity Profiling: Employed in the development and validation of HPLC/GC methods to monitor and control related substances in active pharmaceutical ingredient (API) batches.
• Forensic Analysis: Utilized as an analytical standard in forensic toxicology for the accurate detection and confirmation of tramadol metabolites in biological samples.
• Process Development: Acts as an intermediate in the research-scale synthesis of novel tramadol derivatives or for studying degradation pathways.

Basic Information

Product Name	Rac N,o-Didesmethyl Tramadol
CAS No.	333364-41-3
Molecular Formula	C14H21NO2
Molecular Weight	235.33 g/mol
Synonyms	N,O-Didesmethyltramadol; (±)-N,O-Didesmethyltramadol; rac-N,O-Didesmethyltramadol; 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; Tramadol Metabolite M5; U-09307; 1-(3-Methoxyphenyl)-2-[(dimethylamino)methyl]cyclohexan-1-ol
EINECS	Contact for details

Quality Control

Our Rac N,o-Didesmethyl Tramadol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of related substances. We provide Certificates of Analysis (COA) with detailed results for traceability and compliance. Specifications are aligned with the requirements for high-purity pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.