Description

5-Trans U-46619 is a stable synthetic analog of the thromboxane A2 (TXA2) mimetic, U-46619, specifically designed for research applications. This compound is a critical pharmacological tool for studying the role of thromboxane receptors (TP receptors) in various physiological and pathological processes. It is primarily utilized by researchers and scientists in the fields of cardiovascular biology, pharmacology, and hematology for in vitro and ex vivo studies.

Application

• Pharmacological Research: As a potent and selective TP receptor agonist to investigate receptor signaling pathways and function.
• Cardiovascular Studies: For modeling vasoconstriction, platelet aggregation, and related cardiovascular diseases in laboratory settings.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and evaluate novel thromboxane receptor antagonists.
• Biochemical Assays: A key reagent in studies exploring the mechanisms of hemostasis, thrombosis, and inflammation.
• Academic & Institutional Research: Fundamental tool for university and research institute labs focused on eicosanoid biology and receptor pharmacology.

Basic Information

Product Name	5-Trans U-46619
CAS No.	330796-58-2
Molecular Formula	C₂₁H₃₂O₅
Molecular Weight	364.48 g/mol
Synonyms	9,11-Dideoxy-9α,11α-epoxymethano-prostaglandin F2α (5-trans isomer); 5-trans-U46619; (5Z)-7-[(1R,2R,3R,5S)-3-[(1E,3S)-3-Hydroxy-1-octenyl]-2-(3-oxocyclopentyl)-5-oxocyclopentyl]-5-heptenoic Acid; U-46619 (5-trans isomer); TXA2 Mimetic (5-trans); TP Receptor Agonist (5-trans)
EINECS	Contact for details

Quality Control

Every batch of our 5-Trans U-46619 is manufactured and analyzed under strict quality management protocols to ensure high purity and batch-to-batch consistency essential for reproducible research. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.