Description

5-Chloro-1-[Bis(Dimethylamino)Methylene]-1H-Benzotriazolium 3-Oxide Hexafluorophosphate is a high-purity, advanced coupling reagent widely used in modern organic synthesis. This compound is valued for its exceptional efficiency in facilitating amide bond formation, a critical reaction in pharmaceutical and peptide chemistry. It is an essential tool for research and development chemists, process development scientists, and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries seeking reliable and high-yielding synthetic pathways.

Application

• Primary reagent for amide coupling reactions in peptide synthesis and medicinal chemistry.
• Facilitates the synthesis of complex active pharmaceutical ingredients (APIs) and intermediates under mild conditions.
• Used in the preparation of peptidomimetics and other biologically active compounds.
• Employed in solid-phase peptide synthesis (SPPS) protocols for efficient chain elongation.
• Applicable in the synthesis of macrocyclic compounds and natural product derivatives.
• Valuable for process chemistry and scale-up operations due to its reliability and minimized racemization.

Basic Information

Product Name	5-Chloro-1-[Bis(Dimethylamino)Methylene]-1H-Benzotriazolium 3-Oxide Hexafluorophosphate
CAS No.	330645-87-9
Molecular Formula	C₁₂H₁₆ClF₆N₅OP
Molecular Weight	425.70 g/mol
Synonyms	5-Chloro-1H-benzotriazole-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate; 5-Chloro-HBPyU; 5-Chloro-HBPyU Hexafluorophosphate; 5-Chloro-(1H-Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium Hexafluorophosphate; 5-Chloro-HBTU; 5-Chloro-HBTU Hexafluorophosphate Salt; Chloro-HBTU; Coupling Reagent 5-Chloro-HBTU
EINECS	Contact for details

Quality Control

Our 5-Chloro-1-[Bis(Dimethylamino)Methylene]-1H-Benzotriazolium 3-Oxide Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.