Description

12-(3-Hydroxyethyl)-Cytisine is a chemically modified derivative of the natural alkaloid cytisine, characterized by the addition of a hydroxyethyl functional group. This modification is of significant interest for its potential to alter pharmacological profiles, enhancing its utility in advanced pharmaceutical research and development. This high-purity intermediate is primarily targeted at research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly in the fields of neuroscience and addiction treatment.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates targeting nicotinic acetylcholine receptors (nAChRs).
• Neuroscience Research: Used in biochemical and pharmacological studies to investigate receptor binding, signal transduction, and neuro-modulatory effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop compounds with improved efficacy and selectivity.
• Preclinical Development: Utilized in the formulation of compounds for in vitro and in vivo testing during early-stage drug discovery.

Basic Information

Product Name	12-(3-Hydroxyethyl)-Cytisine
CAS No.	329221-11-6
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	3-(2-Hydroxyethyl)cytisine; N-(2-Hydroxyethyl)cytisine; Cytisine-12-ethanol; 12-(β-Hydroxyethyl)cytisine; (1R,5S)-3-(2-Hydroxyethyl)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
EINECS	Contact for details

Quality Control

Our 12-(3-Hydroxyethyl)-Cytisine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and purity, and is accompanied by a detailed Certificate of Analysis (COA). We support research and development with material that meets stringent specifications for identity, potency, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.