Description

Pi(4,5)P2 Dic 4 CAS NO 329009-41-8 is a high-purity, synthetic phosphatidylinositol phosphate (PIP) derivative, specifically a di-C4 chain variant of phosphatidylinositol 4,5-bisphosphate. This compound serves as a critical biochemical tool and a key intermediate in lipid signaling research and development. It is essential for researchers and manufacturers in the life sciences, pharmaceutical, and biotechnology sectors who require well-defined lipid standards for studying cellular signaling pathways, membrane dynamics, and drug discovery.

Application

• Biochemical Research: As a defined standard for studying phosphoinositide signaling cascades, enzyme kinetics (e.g., phospholipase C), and protein-lipid interactions.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify novel drug candidates targeting lipid-metabolizing enzymes or signaling receptors.
• Lipidomics & Analytical Standards: Serves as a critical reference standard for mass spectrometry (MS) and chromatography-based lipidomic analysis to quantify endogenous PIP species.
• Cell Biology Studies: Employed in membrane biophysics research to investigate the role of specific PIPs in membrane curvature, vesicle formation, and intracellular trafficking.
• Enzyme Substrate: Acts as a substrate for kinases, phosphatases, and lipases in vitro to characterize enzyme activity and specificity.
• Production of Liposomes & Model Membranes: Incorporated into synthetic lipid bilayers and liposomes to create biomimetic systems for drug delivery and membrane protein studies.

Basic Information

Product Name	Pi(4,5)P2 Dic 4
CAS No.	329009-41-8
Molecular Formula	C23H44O19P3
Molecular Weight	756.48 g/mol
Synonyms	1,2-Dibutanoyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate); PI(4,5)P2 diC4; Phosphatidylinositol 4,5-bisphosphate diC4; PtdIns(4,5)P2 (C4); Dipalmitoyl PI(4,5)P2 (Note: This is a common misnomer; "diC4" refers to dibutanoyl, not dipalmitoyl); L-α-Phosphatidylinositol-4,5-bisphosphate (dibutanoyl); PIP2 (4,5) diC4; Inositol phospholipid derivative
EINECS	Contact for details

Quality Control

Our Pi(4,5)P2 Dic 4 is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR, mass spectrometry, and HPLC analysis. Our quality systems are designed to support research and development applications requiring the highest level of material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.