Description

Nicotine-n--Glucuronide, Methyl-D3 is a stable isotope-labeled internal standard, specifically a deuterated metabolite of nicotine. This compound is essential for achieving high-precision quantitative analysis in modern bioanalytical research. It is primarily required by analytical laboratories, CROs, and pharmaceutical R&D departments conducting pharmacokinetic, metabolic, and biomarker studies related to nicotine and tobacco exposure.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of nicotine and its metabolites in biological matrices (e.g., plasma, urine, saliva).
• Pharmacokinetic (PK) Studies: Enables precise tracking of nicotine metabolism and clearance rates in clinical and preclinical research.
• Metabolite Profiling: Used in mass spectrometry to identify and quantify specific glucuronidated metabolic pathways of nicotine.
• Tobacco Exposure Biomarker Research: Facilitates the development and validation of sensitive assays to measure tobacco use and exposure in epidemiological studies.
• Forensic Toxicology: Supports accurate testing for nicotine and cotinine levels in legal and workplace testing scenarios.
• Method Development & Validation: A key reagent for developing, optimizing, and validating robust analytical methods in compliance with FDA, EMA, or other regulatory guidelines.

Basic Information

Product Name	Nicotine-n--Glucuronide, Methyl-D3
CAS No.	329002-74-6
Molecular Formula	C17H21D3N2O7
Molecular Weight	Contact for details
Synonyms	Nicotine N-Glucuronide Methyl-d3; (S)-Nicotine N-β-D-Glucuronide (Methyl-d3); Nicotine N-β-Glucuronide (Methyl-d3); trans-3'-Hydroxycotinine N-Glucuronide-d3 (related metabolite); Nicotine Metabolite-d3; Deuterated Nicotine Glucuronide; Isotopically Labeled Nicotine Standard; Internal Standard for Nicotine Analysis
EINECS	Contact for details

Quality Control

Every batch of Nicotine-n--Glucuronide, Methyl-D3 is produced and tested under strict quality management protocols to ensure identity, purity, and isotopic enrichment. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to ensure compliance with industry standards for reference materials. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity	≥90%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.