Description

Progesterone-[2,3,4-13C3] is a stable isotope-labeled analog of the vital steroid hormone progesterone, specifically enriched with carbon-13 at the 2, 3, and 4 positions. This high-purity labeled compound serves as an essential internal standard for the precise quantification and metabolic profiling of progesterone in complex biological matrices using mass spectrometry. It is a critical tool for researchers and analytical laboratories in pharmaceutical development, clinical diagnostics, and endocrinology research, where accuracy and reliability in hormone measurement are paramount. The product is supplied with a Certificate of Analysis detailing isotopic enrichment and chemical purity.

Application

• Quantitative Mass Spectrometry: Used as an internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of endogenous progesterone in serum, plasma, and tissue samples.
• Metabolic Pathway Tracing: Enables the study of progesterone metabolism, biotransformation, and pharmacokinetics in preclinical and clinical research.
• Pharmaceutical R&D: Critical for the bioanalysis and pharmacokinetic/pharmacodynamic (PK/PD) studies of progesterone-based therapeutics and drug candidates.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity assays for monitoring progesterone levels in fertility, pregnancy, and endocrine disorder assessments.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring method accuracy and compliance in regulated laboratories.
• Doping Control Analysis: Employed in sports anti-doping laboratories for the definitive identification and quantification of exogenous progesterone.

Basic Information

Product Name	Progesterone-[2,3,4-13C3]
CAS No.	327048-87-3
Molecular Formula	C21H3013C3O2
Molecular Weight	~317.5 g/mol (exact mass varies with isotopic enrichment)
Synonyms	13C3-Progesterone; [2,3,4-13C3]Progesterone; 4-Pregnene-3,20-dione-2,3,4-13C3; (8R,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4-13C3-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; Labeled Progesterone; Isotopic Progesterone Standard; Progesterone Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Progesterone-[2,3,4-13C3] is manufactured and analyzed under strict quality control protocols to ensure it meets the high standards required for analytical and research applications. Our quality commitment includes verification of chemical purity (typically >98%) and isotopic enrichment (typically >99 atom % 13C) using advanced techniques like NMR and MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity, isotopic composition, and residual solvents. We support compliance in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider storing desiccated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C at positions 2,3,4
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.