Description

α-[2-[[3-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-1-Oxopropyl]Amino]Ethyl]-ω-[3-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-3-Oxopropoxy]Poly(Oxy-1,2-Ethanediyl) is a specialized heterobifunctional polyethylene glycol (PEG) derivative engineered for advanced bioconjugation and surface functionalization. This compound matters because it provides a versatile, water-soluble linker with reactive maleimide and N-hydroxysuccinimide (NHS) ester termini, enabling the stable and site-specific coupling of biomolecules, polymers, and nanoparticles. It is essential for researchers and manufacturers in pharmaceutical development, diagnostics, and advanced material science who require reliable, high-purity crosslinkers to create next-generation therapeutics and functionalized surfaces.

Application

• Bioconjugation Reagent: For site-specific covalent coupling of peptides, proteins, and antibodies via thiol-maleimide and amine-NHS ester chemistry.
• PEGylation Linker: Used to create PEGylated drug conjugates, improving pharmacokinetics, solubility, and stability of therapeutic agents.
• Surface Functionalization: Immobilization of biomolecules onto biosensor chips, microarrays, and nanoparticle surfaces for diagnostic and research applications.
• Hydrogel Formation: Acts as a crosslinking agent in the synthesis of biocompatible hydrogels for tissue engineering and drug delivery systems.
• Polymer Modification: Introduction of reactive handles onto polymer backbones to create functional materials with tailored properties.
• Diagnostic Assay Development: Conjugation of enzymes or fluorescent probes to antibodies and other detection molecules in immunoassays.

Basic Information

Product Name	α-[2-[[3-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-1-Oxopropyl]Amino]Ethyl]-ω-[3-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-3-Oxopropoxy]Poly(Oxy-1,2-Ethanediyl)
CAS No.	326003-46-7
Molecular Formula	Contact for details
Molecular Weight	Variable (PEG chain length dependent)
Synonyms	Maleimide-PEG-NHS Ester
NHS-PEG-Maleimide
NHS-PEG-MAL
SM(PEG)n (where n denotes PEG unit count)
Poly(ethylene glycol) bis(succinimidyl succinate) derivative
Heterobifunctional PEG crosslinker, Maleimide and NHS terminated
1-{3-[2-(2-{3-[(2,5-Dioxopyrrolidin-1-yl)oxy]-3-oxopropoxy}ethoxy)ethylamino]-3-oxopropyl}pyrrole-2,5-dione
EINECS	Contact for details

Quality Control

Our α-[2-[[3-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-1-Oxopropyl]Amino]Ethyl]-ω-[3-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-3-Oxopropoxy]Poly(Oxy-1,2-Ethanediyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent functional group activity, and low levels of impurities such as diols and moisture. Certificates of Analysis (COA) detailing specifications for identity, assay, and functional group substitution are available upon request. We support compliance with cGMP and ISO 9001 standards for research and pharmaceutical-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with argon or nitrogen purge) to maintain stability of the moisture- and light-sensitive functional groups. For long-term storage, keep product lyophilized or under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
PEG Average Molecular Weight (Mn)	As specified (e.g., 2kDa, 5kDa, 10kDa)
Assay (HPLC)	≥ 95%
Maleimide Substitution	≥ 90%
NHS Ester Substitution	≥ 90%
Moisture (KF)	≤ 1.0%
Solvents (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.