Description

1-Palmitoyl-2-(11,12-Dibromo)Stearoyl-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic brominated phospholipid, specifically designed as a critical reagent for advanced lipid research and development. This compound is essential for studying membrane biophysics, lipid peroxidation, and the structural-functional impact of brominated fatty acyl chains in model bilayer systems. It is primarily utilized by pharmaceutical R&D teams, academic biochemists, and specialty chemical manufacturers focused on lipidomics, drug delivery systems, and novel biomaterial synthesis.

Application

• Biophysical Research: As a key component in constructing model lipid membranes (liposomes, bilayers) to investigate membrane fluidity, phase behavior, and the effects of halogenated lipids.
• Lipid Peroxidation Studies: Serving as a substrate or a structurally defined product analog in research on oxidative stress and lipid damage pathways.
• Pharmaceutical Development: Used in the formulation and testing of lipid-based drug delivery vehicles, such as liposomal carriers, where modified phospholipids can alter stability and targeting.
• Biomaterial Science: Incorporation into functionalized surfaces or matrices to create bioactive coatings or scaffolds with specific interfacial properties.
• Analytical Standard: Acting as a certified reference material (CRM) or internal standard in mass spectrometry-based lipidomic analysis for accurate identification and quantification.
• Enzymology Studies: Employed as a specific substrate for phospholipases (e.g., PLA2) to study enzyme kinetics and inhibition using bromine as a spectroscopic or reactive tag.

Basic Information

Product Name	1-Palmitoyl-2-(11,12-Dibromo)Stearoyl-Sn-Glycero-3-Phosphocholine
CAS No.	324054-54-8
Molecular Formula	C₄₂H₈₂Br₂NO₈P
Molecular Weight	924.89 g/mol
Synonyms	Br2-PSPC; 1-Palmitoyl-2-(11,12-dibromostearoyl)-sn-glycero-3-phosphocholine; (11,12)-Dibromo-PSPC; Brominated Phosphatidylcholine; PC(16:0/18:0(11,12-diBr)); 1-Hexadecanoyl-2-[(11,12-dibromooctadecanoyl)]-sn-glycero-3-phosphocholine; Dibromostearoyl Phosphocholine; L-α-Phosphatidylcholine, 1-palmitoyl-2-(11,12-dibromostearoyl)-
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-(11,12-Dibromo)Stearoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including NMR, HPLC, and mass spectrometry to ensure identity, purity, and lot-to-lot consistency. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 98% (by phosphorus analysis)
Solubility	Soluble in chloroform, methanol, DMSO; forms liposomes in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.