Description

Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-Oh is a synthetic, modified peptide sequence containing a dinitrophenyl (Dnp) fluorescent label. This compound is a critical research-grade biochemical tool, valued for its role in enzyme kinetics studies and as a specific substrate or inhibitor in protease research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutic agents and diagnostic assays.

Application

• Protease/Enzyme Substrate: Used as a specific, fluorogenic substrate for studying the activity, kinetics, and inhibition of various proteolytic enzymes.
• Biochemical Research: Serves as a key reagent in fundamental research on peptide metabolism, protein-protein interactions, and signal transduction pathways.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) assays to identify and characterize potential protease inhibitors for therapeutic applications.
• Diagnostic Assay Development: Acts as a core component in developing sensitive in-vitro diagnostic tests for detecting specific enzymatic activities.
• Academic & Pharmaceutical R&D: Essential for university laboratories and pharmaceutical R&D departments conducting cutting-edge research in biochemistry and medicinal chemistry.

Basic Information

Product Name	Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-Oh
CAS No.	323577-36-2
Molecular Formula	C66H86N18O18
Molecular Weight	1371.5 g/mol
Synonyms	Mca-RPPGFSAFK(Dnp)-OH; (7-Methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-DNP)-OH; Fluorogenic Peptide Substrate Mca-RPPGFSAFK(Dnp)-OH; Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp); ADAMTS13 Fluorogenic Substrate; FRETS-VWF73; VWF73 Peptide; Thrombotic Thrombocytopenic Purpura (TTP) Assay Substrate
EINECS	Contact for details

Quality Control

Every batch of Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high purity and batch-to-batch consistency suitable for sensitive research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.