Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanol (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylethanolamine (PE) with oleoyl chains. This compound is a critical building block in the formulation of advanced lipid-based delivery systems, valued for its ability to form stable, fusogenic membranes. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries developing liposomal drug carriers, mRNA vaccines, and other nanomedicines.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key structural phospholipid for creating stable, fusogenic bilayers in drug delivery vesicles and mRNA vaccine carriers.
• Cell Membrane Research & Model Systems: Used to construct synthetic membranes that mimic the fluidity and properties of natural cell membranes for biophysical studies.
• Drug Delivery Enhancement: Incorporated into nanoemulsions and micelles to improve the solubility, bioavailability, and targeted delivery of poorly soluble active pharmaceutical ingredients (APIs).
• Bioconjugation & Surface Functionalization: Serves as an anchor point for attaching targeting ligands (e.g., antibodies, peptides) to lipid nanoparticle surfaces.
• Cosmetic & Dermal Delivery Systems: Used in advanced cosmetic formulations for encapsulating and stabilizing active ingredients for enhanced skin penetration.
• Diagnostic Reagent Preparation: A component in the formulation of reagents for diagnostic assays and imaging contrast agents.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanol (Sodium Salt)
CAS No.	322647-53-0
Molecular Formula	C41H78NO8PNa
Molecular Weight	766.02 g/mol
Synonyms	DOPE (sodium salt); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, sodium salt; DOPE-Na; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl (2-aminoethoxy)(hydroxy)phosphinate, sodium salt; Phosphatidylethanolamine (18:1), sodium salt; DOPEA-Na; PE(18:1/18:1) sodium salt; L-α-Phosphatidylethanolamine-Dioleoyl (sodium salt)
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanol (Sodium Salt) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Peroxide Value	< 3.0 meq/kg
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.