Description

α-Maleinimido-ω-Carboxy Poly(Ethylene Glycol) (Peg-Mw 10.000 Dalton) CAS NO 321936-04-3 is a heterobifunctional PEG derivative featuring a maleimide group at one terminus and a carboxylic acid at the other, designed for advanced bioconjugation and crosslinking applications. This compound is critical for creating stable, site-specific linkages between biomolecules, such as antibodies, peptides, and proteins, with other functional entities. It is essential for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science who require precise and reliable conjugation tools.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies for targeted cancer therapies.
• Protein-Polymer Conjugation: PEGylation of therapeutic proteins to enhance solubility, stability, and circulation half-life.
• Diagnostic Probe Assembly: Conjugation of detection labels (e.g., fluorophores, enzymes) to antibodies or oligonucleotides for ELISA, flow cytometry, and in-vivo imaging.
• Surface Functionalization: Modification of nanoparticles, biosensors, or chromatographic media with bioactive ligands for targeted interactions.
• Hydrogel Formation: Crosslinking agent for creating biocompatible, PEG-based hydrogels used in tissue engineering and drug delivery systems.
• Peptide & Small Molecule Conjugation: Creating stable, defined conjugates for research and pre-clinical development.

Basic Information

Product Name	α-Maleinimido-ω-Carboxy Poly(Ethylene Glycol) (Peg-Mw 10.000 Dalton)
CAS No.	321936-04-3
Molecular Formula	C2n+6H4n+8N2On+5 (n ~ 227 for MW 10k)
Molecular Weight	~10,000 Dalton (Average Molecular Weight)
Synonyms	Maleimide-PEG10k-COOH; MAL-PEG10k-Acid; 3-Maleimidopropionic Acid-PEG10k-Acid; α-Maleimido-ω-carboxy PEG; mPEG-MAL-COOH, MW 10,000; Heterobifunctional PEG Maleimide Carboxylic Acid; N-(3-Carboxypropyl)maleimide-PEG10k-acid; Poly(ethylene glycol) bis(3-maleimidopropionate) derivative
EINECS	Contact for details

Quality Control

Our α-Maleinimido-ω-Carboxy PEG 10k is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity, suitable for sensitive bioconjugation work. Certificates of Analysis (COA) providing detailed specifications from NMR, HPLC, and titration methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Complies
Average Molecular Weight (GPC)	9,500 - 10,500 Da
Polydispersity Index (PDI)	≤ 1.05
Maleimide Content (UV)	≥ 95%
Carboxylic Acid Content (Titration)	≥ 95%
Purity (HPLC)	≥ 95%
Moisture Content (KF)	≤ 1.0%
Solubility	Clear, colorless solution in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.