Description

1-Palmitoyl-2-Stearoyl-(14-Doxyl)-Sn-Glycero-3-Phosphocholine is a specialized, spin-labeled phospholipid analog designed for advanced biophysical and membrane research. This compound matters because it incorporates a stable nitroxide radical (doxyl) reporter group at a defined position on the sn-2 acyl chain, enabling precise investigation of membrane dynamics, fluidity, and protein-lipid interactions using techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. Researchers in structural biology, pharmaceutical development, and advanced material science need this high-purity, well-defined probe to create accurate membrane models and study molecular behavior in lipid bilayers.

Application

• Membrane Biophysics Research: As a spin probe for Electron Paramagnetic Resonance (EPR) spectroscopy to study lipid bilayer fluidity, phase transitions, and lateral organization.
• Protein-Lipid Interaction Studies: To investigate the binding, orientation, and dynamics of membrane-associated proteins and peptides within a controlled phospholipid environment.
• Model Membrane Systems: A key component in the formulation of liposomes, supported lipid bilayers (SLBs), and nanodiscs for creating well-defined experimental platforms.
• Antioxidant & Free Radical Research: Utilizing the nitroxide label to study redox processes, radical scavenging, and oxidative stress within lipid membranes.
• Drug Delivery & Formulation Science: Used in the development and characterization of lipid-based nanoparticle carriers to understand drug incorporation and release mechanisms.
• Membrane Sensor Development: Serving as a reporter molecule in the design of biosensors that detect changes in membrane properties or the presence of specific analytes.

Basic Information

Product Name	1-Palmitoyl-2-Stearoyl-(14-Doxyl)-Sn-Glycero-3-Phosphocholine
CAS No.	321595-12-4
Molecular Formula	C₄₃H₈₄NO₈P
Molecular Weight	778.10 g/mol
Synonyms	16:0-18:0(14-doxyl)-PC; 1-Palmitoyl-2-stearoyl-(14-doxyl)-PC; 14-Doxyl-PSPC; PC(16:0/18:0(14-doxyl)); Spin-labeled phosphatidylcholine; Doxyl-labeled phospholipid; 1-Palmitoyl-2-stearoyl-(14-doxyl)-sn-glycero-3-phosphocholine; Nitroxide-labeled PC
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Stearoyl-(14-Doxyl)-Sn-Glycero-3-Phosphocholine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and EPR to confirm spin label integrity and concentration. A detailed Certificate of Analysis (COA) providing full specification data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Spin Label Integrity (EPR)	≥ 90% active radical
Solubility	Soluble in chloroform, ethanol; forms vesicles in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.