Description

1 2-Dioleoyl-Sn-Glycero-3-Phospho-L-Seri CAS NO 321595-11-3 is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylserine (PS) with oleoyl chains. This compound is a critical functional component in the formulation of advanced lipid-based delivery systems, offering superior biocompatibility and membrane-fusion properties. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation liposomal drug carriers, diagnostic agents, and cell culture media supplements.

Application

• Liposomal Drug Delivery: A key excipient for creating stable, long-circulating, and target-specific liposomes for cancer therapeutics, vaccines, and gene therapy.
• Biomimetic Membrane Research: Used to construct model cell membranes (e.g., supported lipid bilayers, vesicles) for studying membrane protein interactions, signaling, and fusion events.
• Diagnostic Reagent Formulation: Incorporated into contrast agents for medical imaging (e.g., ultrasound) and as a component in assay kits for phospholipid metabolism studies.
• Cell Culture & Neuroscience: Serves as a supplement in serum-free media formulations and is used in research on apoptosis, neuronal function, and cognitive health.
• Cosmetic & Dermal Formulations: Employed in high-end cosmetic products for its skin-restorative and barrier-enhancing properties.
• Biophysical & Biochemical Studies: A standard reagent for calorimetry (DSC), fluorescence, and NMR studies to understand lipid bilayer dynamics and thermodynamics.

Basic Information

Product Name	1 2-Dioleoyl-Sn-Glycero-3-Phospho-L-Seri
CAS No.	321595-11-3
Molecular Formula	C45H82NO10P
Molecular Weight	810.11 g/mol
Synonyms	DOPS; 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt); L-α-Phosphatidylserine (DOPS); (2S)-2-Amino-3-({[(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy](hydroxy)phosphoryl}oxy)propanoic acid; Phosphatidylserine (18:1); PS (18:1/18:1); OOPS; Dioleoylphosphatidylserine
EINECS	Contact for details

Quality Control

Our 1 2-Dioleoyl-Sn-Glycero-3-Phospho-L-Seri is manufactured under strict quality systems suitable for pharmaceutical R&D and commercial applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, purity, and lipid composition. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, ensuring traceability and compliance with your internal specifications and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. For long-term stability, the product should be kept desiccated to protect against moisture. Allow the vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0% (Area Percent)
Assay (Phosphorus Content)	≥ 95.0%
Solubility	Soluble in chloroform, ethanol; forms liposomes in aqueous buffers
Residual Solvents (GC)	Meets ICH guidelines
Peroxide Value	< 5.0 mEq/kg
Lyso-Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.