Description

Br-PEG6-Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a bromo (Br) group at one terminus and a carboxylic acid (COOH) group at the other, separated by a hexaethylene glycol spacer. This compound is a crucial building block in bioconjugation and pharmaceutical development, enabling the controlled, site-specific linkage of molecules for applications like drug delivery and diagnostics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, functionalized linkers for creating novel therapeutics and diagnostic agents.

Application

• Bioconjugation and ADC Development: Serves as a versatile linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) synthesis, leveraging the bromo group for thiol conjugation and the acid for amine coupling.
• PEGylation Reagent: Used to PEGylate peptides, proteins, and small molecule drugs to improve solubility, prolong circulation half-life, and reduce immunogenicity.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker in surface chemistry and hydrogel formation for creating functionalized biomaterials.
• Polymer and Dendrimer Synthesis: A key monomer for constructing functionalized PEG-based polymers, dendrimers, and micelles with tailored properties.
• Diagnostic Probe Synthesis: Facilitates the development of imaging probes and biosensors by linking targeting moieties to reporter molecules.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a soluble polymer support or as a functional handle for on-resin modifications.

Basic Information

Product Name	Br-PEG6-Acid
CAS No.	309916-91-4
Molecular Formula	C17H33BrO8
Molecular Weight	469.35 g/mol
Synonyms	1-Bromo-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid; 2-[2-[2-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; Bromo-PEG6-acid; Br-PEG6-COOH; Bromohexaethylene glycol acetic acid; α-Bromo-ω-carboxy hexaethylene glycol; Bromo-PEG(6)-acid; Bromo-PEG6-Acid
EINECS	Contact for details

Quality Control

Our Br-PEG6-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.