Description

Angiotensin I Converting Enzyme 2, (Ace-2) Substrate is a specialized peptide sequence designed for the specific study of the ACE2 enzyme. This compound is a critical research tool for investigating the renin-angiotensin system (RAS), viral entry mechanisms, and cardiovascular physiology. It is essential for pharmaceutical R&D, academic biochemistry, and diagnostic development laboratories focused on metabolic and infectious disease pathways.

Application

• Enzyme Kinetics & Inhibition Studies: Primary substrate for determining ACE2 enzyme activity, kinetic parameters (Km, Vmax), and screening for potential inhibitors.
• Biochemical Assay Development: Key component in developing in vitro fluorometric or colorimetric assays to measure ACE2 concentration and function in biological samples.
• Cardiovascular & Renal Disease Research: Used to model and study the role of the ACE2/Ang-(1-7)/Mas receptor axis in hypertension, heart failure, and diabetic nephropathy.
• Infectious Disease Research: Vital for studying the interaction between ACE2 and viral proteins, particularly in coronavirus entry research, to understand infection mechanisms and develop therapeutic interventions.
• Pharmaceutical Drug Discovery: High-throughput screening (HTS) of compound libraries for novel ACE2 modulators, activators, or protective agents.
• Diagnostic Reagent Manufacturing: Serves as a core reagent in the production of ELISA kits and other diagnostic tests designed to detect ACE2 activity or autoantibodies.

Basic Information

Product Name	Angiotensin I Converting Enzyme 2, (Ace-2) Substrate
CAS No.	305336-82-7
Molecular Formula	C44H62N12O12
Molecular Weight	926.02 g/mol
Synonyms	ACE2 Substrate; Angiotensin-Converting Enzyme 2 Substrate; Mca-APK(Dnp); 7-Methoxycoumarin-4-acetyl-APK(Dnp); Fluorogenic ACE2 Substrate; Mca-Ala-Pro-Lys(Dnp); SARS-CoV-2 Receptor Substrate; RAS Research Peptide
EINECS	Contact for details

Quality Control

Every batch of our ACE2 Substrate is manufactured and tested to meet stringent research-grade specifications. We employ advanced analytical techniques, including HPLC and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance in standard assay conditions is provided with each shipment to support your critical research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Functional Activity	≥ 90% relative activity in standard ACE2 assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.