Description

1α,26-Dihydroxy Vitamin D3 is a biologically active metabolite of Vitamin D3, representing a key intermediate in the hormonal calcitriol pathway. This compound is critical for research and development in the life sciences, particularly for studying calcium homeostasis, cell differentiation, and immune system modulation. It is essential for pharmaceutical R&D teams, academic researchers, and manufacturers focused on endocrinology, oncology, and metabolic bone disease therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in drug manufacturing.
• Biochemical Research: Used in in vitro and in vivo studies to investigate Vitamin D receptor (VDR) activation and downstream signaling pathways.
• Drug Discovery & Development: A vital intermediate for the synthesis of novel Vitamin D analogs with potential therapeutic applications.
• Metabolic Studies: Employed to elucidate the complex metabolism of Vitamin D3 and the biological roles of its various hydroxylated derivatives.
• Cell Culture & Differentiation: Applied in research on the role of Vitamin D metabolites in regulating cell growth and differentiation, particularly in bone and immune cells.

Basic Information

Product Name	1α,26-Dihydroxy Vitamin D3
CAS No.	300692-92-6
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	1α,26-Dihydroxycholecalciferol; 1α,26-Dihydroxyvitamin D3; 1α,26-Dihydroxy-D3; (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-Dihydroxy-3-methylpentyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
EINECS	Contact for details

Quality Control

Our 1α,26-Dihydroxy Vitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.