Description

4-Hydroxymelatonin is a primary metabolite of melatonin, offering a critical reference standard and research compound for studying melatonin's metabolic pathways and antioxidant mechanisms. This compound is essential for analytical and pharmacological research, providing insights into neuroprotective effects and circadian rhythm regulation. It is primarily utilized by research institutions, pharmaceutical R&D departments, and analytical laboratories focused on endocrinology, sleep science, and oxidative stress studies.

Application

• Biochemical Research: Used as a key metabolite standard in studies investigating the pharmacokinetics, metabolism, and bioavailability of melatonin.
• Analytical Reference Standard: Serves as a high-purity calibrant for HPLC, LC-MS, and GC-MS methods in clinical and forensic toxicology laboratories.
• Pharmaceutical Development: Employed in the research and development of novel therapeutics targeting sleep disorders, neurodegenerative diseases, and antioxidant formulations.
• Metabolite Profiling: Critical for in vitro and in vivo studies to map melatonin's metabolic fate and identify its active derivatives.
• Antioxidant Studies: Utilized in research models to evaluate and compare the radical-scavenging and cytoprotective activities of melatonin and its metabolites.

Basic Information

Product Name	4-Hydroxymelatonin
CAS No.	39998-64-6
Molecular Formula	C₁₃H₁₆N₂O₂
Molecular Weight	232.28 g/mol
Synonyms	N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide; 5-Hydroxymelatonin; Melatonin, 5-hydroxy-; 4-Hydroxy-N-acetyl-5-methoxytryptamine; 5-Hydroxy-N-acetyl-5-methoxytryptamine; 5-Hydroxy-N-acetyltryptamine; 5-Hydroxy-N-acetylserotonin methyl ether
EINECS	Contact for details

Quality Control

Our 4-Hydroxymelatonin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets high-purity research-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.