Description

7,12-Dimethylbenz(A)Anthracene 5,6-Oxide is a high-purity, synthetically produced epoxide derivative of the polycyclic aromatic hydrocarbon (PAH) DMBA. This compound is of significant value as a critical reference standard and reactive intermediate in advanced chemical and biochemical research. It is primarily required by pharmaceutical R&D laboratories, toxicology research institutes, and academic institutions for mechanistic studies involving metabolic activation, DNA adduct formation, and carcinogenicity pathways.

Application

• Biochemical Research: Used as a key metabolite and electrophilic intermediate in studies of polycyclic aromatic hydrocarbon (PAH) metabolic activation and carcinogenesis.
• Toxicology & Safety Assessment: Serves as a critical reference standard for calibrating analytical methods (HPLC, GC-MS) used in genotoxicity and mutagenicity testing.
• Pharmaceutical Development: Employed in mechanistic studies to understand DNA damage and adduct formation, aiding in the development of chemopreventive agents.
• Academic Research: Essential for fundamental research in organic chemistry, specifically in reactions of arene oxides and their role in biochemical pathways.
• Analytical Standard: Provides a high-purity benchmark for quantifying DMBA and its metabolites in complex environmental or biological matrices.

Basic Information

Product Name	7,12-Dimethylbenz(A)Anthracene 5,6-Oxide
CAS No.	39834-38-3
Molecular Formula	C₂₀H₁₄O
Molecular Weight	270.33 g/mol
Synonyms	DMBA 5,6-oxide; 7,12-DMBA-5,6-oxide; 5,6-Epoxy-7,12-dimethylbenz[a]anthracene; Benz[a]anthracene, 5,6-epoxy-7,12-dimethyl-; 7,12-Dimethylbenz[a]anthracene 5,6-epoxide; (+/-)-7,12-Dimethylbenz[a]anthracene-5,6-oxide; Anti-7,12-Dimethylbenz[a]anthracene-5,6-oxide
EINECS	Contact for details

Quality Control

Our 7,12-Dimethylbenz(A)Anthracene 5,6-Oxide is manufactured under strict controls to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to rigorous internal quality standards to meet the exacting requirements of the scientific research community.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Solubility	Soluble in DMSO, DMF; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.