Description

Potassium Dextran Sulfate is a sulfated polysaccharide derivative of dextran, where the hydroxyl groups are substituted with sulfate groups and the counterion is potassium. This compound is valued for its strong anionic character and ability to interact with proteins and other biomolecules, making it a critical reagent in biochemical and pharmaceutical research. It is primarily utilized by researchers and manufacturers in the life sciences, diagnostics, and pharmaceutical development sectors for its unique physicochemical properties.

Application

• Biochemical Research: Used as a precipitating agent for lipoproteins and in the study of enzyme inhibition, particularly for lipases and proteases.
• Diagnostic Reagents: A key component in clinical chemistry test kits for the quantitative determination of cholesterol, specifically in precipitating low-density lipoproteins (LDL).
• Cell Culture & Virology: Employed to inhibit viral infection in cell-based assays and to study the role of sulfated polysaccharides in cell surface interactions.
• Pharmaceutical Development: Investigated for its potential anticoagulant and anti-inflammatory properties in drug discovery programs.
• Chromatography: Can be used as a ligand in affinity chromatography for the purification of specific binding proteins.
• Standard & Reference Material: Serves as a calibrated standard in analytical laboratories for method development and quality control.

Basic Information

Product Name	Potassium Dextran Sulfate
CAS No.	39422-86-1
Molecular Formula	(C6H7KO11S2)n
Molecular Weight	Variable (Polymer)
Synonyms	Dextran Sulfate Potassium Salt; Dextran Potassium Sulfate; Potassium Dextran Sulphate; Dextran Sulphate Potassium; Dextran Sulfate K; DSS; DS-K; Dextran Sulfate (Potassium Salt)
EINECS	Contact for details

Quality Control

Our Potassium Dextran Sulfate is manufactured under a strict quality management system. Each batch is tested to ensure it meets stringent specifications for identity, purity, and performance. Certificates of Analysis (COA) detailing parameters such as sulfate content, molecular weight distribution, and biological activity are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (Sulfate Content)	16.0 - 20.0 %
pH (1% Solution)	5.0 - 7.5
Loss on Drying	≤ 7.0 %
Heavy Metals (as Pb)	≤ 20 ppm
Molecular Weight (Average)	Specified grade dependent (e.g., 5kDa, 40kDa, 500kDa)
Biological Activity (Lipoprotein Precipitation)	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.