Description

Hemoglobin M Boston CAS NO 39340-61-9 is a stable, naturally occurring variant of hemoglobin, a critical oxygen-transporting protein in red blood cells. This specific mutant form is of significant research interest for studying the structure-function relationships in hemoglobinopathies and oxygen-binding mechanisms. It serves as an essential biochemical tool for researchers and developers in the life sciences sector, particularly those investigating genetic blood disorders and protein engineering.

Application

• Biochemical Research: Used as a reference standard and model compound in studies of hemoglobin structure, function, and stability.
• Hematology Studies: Critical for investigating the pathophysiology of congenital methemoglobinemia and other hemoglobin M diseases.
• Diagnostic Development: Serves as a key component in the development and calibration of diagnostic assays for detecting abnormal hemoglobins.
• Pharmaceutical Research: Utilized in drug discovery programs targeting sickle cell disease, thalassemia, and other hemoglobin disorders.
• Educational & Reference Material: Supplied to academic and clinical laboratories for teaching and quality control purposes.
• Spectroscopic Studies: Employed in UV-Vis, EPR, and other spectroscopic analyses due to its distinct spectral properties.

Basic Information

Product Name	Hemoglobin M Boston
CAS No.	39340-61-9
Molecular Formula	C2952H4664N812O832S40Fe4 (Approximate, for α2M Bostonβ2)
Molecular Weight	~64,500 Da (Tetramer)
Synonyms	Hb M Boston; Hemoglobin α258(E7)His→Tyrβ2; Hemoglobin αHis58→Tyr; Methemoglobin M Boston; HBA1 p.His58Tyr; α2M Bostonβ2; Abnormal Hemoglobin M; Congenital Methemoglobinemia Type I (α-variant)
EINECS	Contact for details

Quality Control

Our Hemoglobin M Boston is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot is characterized using advanced analytical techniques including HPLC, electrophoresis, and spectrophotometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, spectral characteristics, and physical form is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. Under these recommended conditions, the product is stable for extended periods.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (UV-Vis)	Conforms to reference spectrum for Hb M Boston
Purity (HPLC)	≥ 90% (Hb M Boston tetramer)
Methemoglobin Content	> 95%
Protein Concentration	As stated on COA
Solvent/Buffer	Specified on COA
Endotoxin Level	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.