Description

Trimethylamine Dehydrogenase is a highly specialized enzyme that catalyzes the oxidation of trimethylamine (TMA) to trimethylamine N-oxide (TMAO). This reaction is critical in microbial metabolism and serves as a key model system for studying electron transfer in complex metalloenzymes. It is an essential research tool for biochemists, enzymologists, and microbiologists working in academic research, pharmaceutical development, and industrial biotechnology.

Application

• Enzymology Research: Fundamental studies on enzyme kinetics, mechanism, and structure-function relationships.
• Metabolic Pathway Analysis: Investigation of microbial trimethylamine metabolism and its implications in environmental and gut microbiomes.
• Biocatalyst Development: Potential use in enzymatic assays or as a component in biosensor development for TMA detection.
• Protein Biochemistry: A model protein for studying complex redox cofactors, including iron-sulfur clusters and molybdopterin.
• Pharmaceutical Research: Studying the TMA/TMAO pathway linked to cardiovascular disease and other metabolic disorders.
• Educational Use: A teaching tool for advanced biochemistry and molecular biology courses.

Basic Information

Product Name	Trimethylamine Dehydrogenase
CAS No.	39307-09-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TMA Dehydrogenase; Trimethylamine:(acceptor) oxidoreductase (demethylating); EC 1.5.8.2; TMA-DH; Trimethylamine oxidase (ambiguous); Methylomonas aminofaciens trimethylamine dehydrogenase
EINECS	Contact for details

Quality Control

Our Trimethylamine Dehydrogenase is produced and handled under stringent conditions to ensure high purity, specific activity, and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including activity assays and purity assessments. Certificates of Analysis (COA) detailing specific activity, protein concentration, and purity are provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after use to prevent degradation.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Catalyzes oxidation of Trimethylamine
Specific Activity	Contact for details (Units/mg protein)
Purity (SDS-PAGE)	> 90%
Protein Concentration	Contact for details
Buffer Composition	Contact for details
Stabilizers/Additives	None (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.