Description

Methimazole Thio-B-D-Glucuronide is a key glucuronide metabolite of the antithyroid drug methimazole. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism, toxicology, and analytical method development.

Application

• Reference Standard for Analytical Chemistry: Used as a high-purity standard for the quantification and identification of methimazole metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Pharmacokinetic and ADME Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of methimazole, helping to understand its in vivo behavior.
• Metabolic Pathway Elucidation: Serves as a critical tool for mapping and validating the phase II conjugation pathways of methimazole, specifically glucuronidation.
• Toxicology and Safety Assessment: Employed in studies to assess the potential toxicity and safety profile of methimazole and its metabolic products.
• Biomarker Development: Can be utilized in the development of clinical biomarkers to monitor methimazole therapy and patient compliance.
• Enzyme Kinetics Research: Used as a substrate in studies to characterize the activity and specificity of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Methimazole Thio-B-D-Glucuronide
CAS No.	39038-19-2
Molecular Formula	C10H14N2O6S
Molecular Weight	290.29 g/mol
Synonyms	1-Methyl-2-imidazolidinethione 3-β-D-Glucuronide; Methimazole β-D-Glucuronide; Thiamazole Glucuronide; 1-Methyl-1,3-dihydro-2H-imidazole-2-thione 3-β-D-Glucopyranosiduronic Acid; Tapazole Glucuronide; Mercazole Glucuronide; 3-(β-D-Glucopyranuronosyl)thiamazole
EINECS	Contact for details

Quality Control

Our Methimazole Thio-B-D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in pharmaceutical development and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content	≤ 5.0%
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.