Description

Jacobine N‐Oxide is a pyrrolizidine alkaloid derivative, a compound of significant interest in advanced chemical synthesis and research. Its oxidized nitrogen functionality makes it a valuable intermediate for developing novel pharmacologically active molecules and specialized fine chemicals. This product is primarily utilized by research institutions and industrial laboratories in the pharmaceutical, agrochemical, and life science sectors for process development and analytical reference standards.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex alkaloid-based drug candidates and reference compounds for metabolic studies.
• Biochemical Research: Used as a standard or reagent in studies investigating pyrrolizidine alkaloid metabolism, toxicity, and detoxification pathways.
• Agrochemical Development: Serves as a precursor or model compound in the research and development of new plant-derived bioactive agents.
• Analytical Chemistry: Employed as a high-purity certified reference material (CRM) for method development and calibration in HPLC, LC-MS, and GC-MS analyses.
• Academic Research: Fundamental research tool in organic chemistry and natural product chemistry for studying N-oxidation reactions and alkaloid properties.

Basic Information

Product Name	Jacobine N‐Oxide
CAS No.	38710-25-7
Molecular Formula	C18H25NO7
Molecular Weight	367.40 g/mol
Synonyms	Jacobine N-Oxide; Jacobine 1-oxide; 12,18-Epoxy-11-(hydroxymethyl)-7-methyl-6,7,8,9-tetrahydro-11H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,3,4,13-tetrol 13-acetate 2,3-dihydroxy-2-(1-hydroxyethyl)-3-methylbutanoate 1-oxide; (1R,2R,7S,8S)-12,18-Epoxy-11-(hydroxymethyl)-7-methyl-6,7,8,9-tetrahydro-11H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,3,4,13-tetrol 13-acetate 2,3-dihydroxy-2-(1-hydroxyethyl)-3-methylbutanoate 1-oxide
EINECS	Contact for details

Quality Control

Our Jacobine N‐Oxide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under inert atmosphere is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.