Description

Phenoxyacetic Acid n-Hydroxysuccinimide Ester is a high-purity, reactive chemical intermediate designed for advanced synthesis. This compound is a critical reagent for the efficient formation of stable amide bonds, enabling the conjugation of phenoxyacetic acid derivatives to primary amines. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and agrochemical sectors who require reliable, high-yield coupling agents for peptide synthesis, protein labeling, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation Reagent: Used for labeling proteins, antibodies, and peptides with phenoxyacetyl groups for diagnostic and therapeutic applications.
• Peptide Synthesis: Facilitates the incorporation of phenoxyacetic acid motifs into peptide chains during solid-phase or solution-phase synthesis.
• Agrochemical Research: Intermediate in the development of new herbicides and plant growth regulators with phenoxyacetic acid backbones.
• Linker Chemistry: Employed in the construction of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted therapies.
• Material Science: Used to functionalize surfaces and polymers with bioactive phenoxyacetyl groups.

Basic Information

Product Name	Phenoxyacetic Acid n-Hydroxysuccinimide Ester
CAS No.	38678-58-9
Molecular Formula	C12H11NO5
Molecular Weight	249.22 g/mol
Synonyms	N-Hydroxysuccinimide Phenoxyacetate; NHS-Phenoxyacetate; Phenoxyacetic Acid N-Hydroxysuccinimide Ester; Phenoxyacetyloxysuccinimide; 2-Phenoxyacetic Acid N-Hydroxysuccinimide Ester; Succinimidyl Phenoxyacetate; NSC 334358; 1-[(2-Phenoxyacetyl)oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our Phenoxyacetic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.