Description

1-Piperazinecarbodithioic Acid, 4-Methyl-, Succinimidomethyl Ester is a specialized heterocyclic compound featuring a piperazine core functionalized with a dithiocarbamate and an N-hydroxysuccinimide (NHS) ester group. This bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced research compounds. It is primarily utilized by pharmaceutical R&D teams, agrochemical manufacturers, and specialty chemical producers seeking to introduce specific reactive handles for conjugation or further chemical elaboration.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting neurological or oncological pathways.
• Bioconjugation Reagent: The NHS ester moiety enables efficient coupling to primary amines, making it useful for labeling proteins, peptides, and other biomolecules.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and pesticides.
• Polymer Modification: Used to introduce functional groups into polymer chains to alter material properties like adhesion or biocompatibility.
• Research & Development: Serves as a critical reagent in medicinal chemistry and chemical biology for probe and linker synthesis.
• Chelating Agent Precursor: The dithiocarbamate group can be leveraged to create metal-chelating compounds for various industrial processes.

Basic Information

Product Name	1-Piperazinecarbodithioic Acid, 4-Methyl-, Succinimidomethyl Ester
CAS No.	38221-41-9
Molecular Formula	C11H17N3O2S2
Molecular Weight	287.40 g/mol
Synonyms	4-Methylpiperazine-1-carbodithioic acid N-hydroxysuccinimide ester; N-Succinimidyl 4-methylpiperazine-1-carbodithioate; NHS-PDTC; 1-(Succinimidoxycarbonyl)-4-methylpiperazine-1-carbodithioate; SMPT; 4-Methyl-1-piperazinecarbodithioic acid 2,5-dioxo-1-pyrrolidinyl ester; Piperazine-1-carbodithioic acid, 4-methyl-, 2,5-dioxo-1-pyrrolidinyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Piperazinecarbodithioic Acid, 4-Methyl-, Succinimidomethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with cGMP standards for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.