Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Valerate) CAS NO 38196-44-0 is a synthetic corticosteroid derivative, specifically a diester prodrug of a potent glucocorticoid. This compound is of significant interest in advanced pharmaceutical research and development due to its potential for enhanced topical activity and modified pharmacokinetic profiles. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel corticosteroid-based drugs.
• Anti-inflammatory Agent R&D: Investigated for its potential topical anti-inflammatory activity in dermatological formulations.
• Immunosuppressive Research: Used in preclinical studies exploring new immunosuppressive therapies for autoimmune conditions.
• Prodrug Development: Studied as a model compound for designing ester prodrugs to improve drug delivery, solubility, or duration of action.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Used in studies to understand glucocorticoid receptor interactions and steroid metabolism.

Basic Information

Item	Detail
Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Valerate)
CAS No.	38196-44-0
Molecular Formula	C31H43FO7
Molecular Weight	546.68 g/mol
Synonyms	Flumethasone Pivalate (common name); Flumethasone 17,21-Dipivalate; Flumethasone Pivalate (USP); SQ 15102; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-dipivalate; Flumetasone Pivalate; Flumethasone Dipivalate; NSC 107687
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Valerate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.