Description

Polyprenylpyrophosphate is a crucial biosynthetic intermediate in the isoprenoid pathway, serving as the direct precursor for the synthesis of various essential biomolecules. Its primary commercial value lies in its role as a key substrate for enzymatic synthesis and biochemical research, enabling the study and production of compounds like dolichols, ubiquinones, and carotenoid precursors. This high-purity biochemical is essential for researchers and manufacturers in the pharmaceutical, nutraceutical, and life science research sectors, where precise control over biosynthetic pathways is required.

Application

• Enzymatic Synthesis Substrate: Critical precursor for in-vitro enzymatic synthesis of longer-chain polyprenols and dolichols.
• Biochemical Research: Used in studies of the mevalonate and non-mevalonate (MEP/DOXP) pathways to understand isoprenoid biosynthesis.
• Pharmaceutical Intermediates: Serves as a building block for the research and development of compounds targeting cholesterol synthesis, protein glycosylation, and mitochondrial function.
• Nutraceutical Precursor: Involved in the research and production pathways for coenzyme Q10 (ubiquinone) and other lipid-soluble antioxidants.
• Cell Biology Studies: Employed in investigations of protein prenylation, a key post-translational modification affecting cell signaling and membrane association.
• Reference Standard: Used as a high-purity analytical standard in HPLC and LC-MS methods for quantifying isoprenoid intermediates in biological samples.

Basic Information

Product Name	Polyprenylpyrophosphate
CAS No.	38095-90-8
Molecular Formula	C55H92O7P2 (for a typical prenyl chain length; variable)
Molecular Weight	~927.3 g/mol (for C55 chain; variable based on prenyl units)
Synonyms	Polyprenyl pyrophosphate; Prenyl pyrophosphate (long-chain); All-trans-polyprenyl diphosphate; Undecaprenyl pyrophosphate (specific isomer); Dolichyl pyrophosphate precursor; Isoprenoid pyrophosphate; (2E,6E)-Farnesyl pyrophosphate (for shorter chains); Geranylgeranyl pyrophosphate (GGPP); Solanesyl pyrophosphate
EINECS	Contact for details

Quality Control

Our Polyprenylpyrophosphate is produced under stringent conditions to ensure batch-to-batch consistency and high chemical purity suitable for research and synthesis. Each lot undergoes comprehensive analytical characterization. A detailed Certificate of Analysis (COA) is provided, documenting purity, identity, and stability data. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Area Percent)
Purity (TLC)	Single major spot
Solubility	Soluble in chloroform, methanol; slightly soluble in aqueous buffer
Water Content (KF)	≤ 1.0 %
Pyrophosphate Integrity (NMR)	Intact pyrophosphate moiety confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.