Description

Gtp-γ-S Sodium Salt is a high-purity nucleotide analog essential for biochemical research and diagnostic applications. This compound serves as a critical substrate and energy source in enzymatic reactions, particularly those involving kinases and GTP-binding proteins. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic kit manufacturers for studies in signal transduction, molecular biology, and assay development.

Application

• Biochemical Research: As a substrate for GTPase and kinase activity assays to study cellular signaling pathways.
• Pharmaceutical Development: Used in high-throughput screening (HTS) to identify and characterize potential drug candidates targeting G-proteins.
• Diagnostic Assays: A key component in enzymatic diagnostic kits for measuring specific biomarker activities.
• Enzymology Studies: Employed to investigate the kinetics and mechanisms of nucleotide-dependent enzymes.
• Cell Biology: Used in experiments to modulate intracellular GTP levels and observe effects on cell function and proliferation.
• Molecular Biology: Acts as a critical reagent in transcription and translation studies in vitro.

Basic Information

Product Name	Gtp-γ-S Sodium Salt
CAS No.	37589-80-3
Molecular Formula	C10H12N5O14P3S · xNa
Molecular Weight	Approx. 563.1 (Free acid)
Synonyms	Guanosine 5'-[γ-thio]triphosphate sodium salt; GTPγS sodium salt; Guanosine-5'-(3-thiotriphosphate) sodium salt; 5'-Guanosyl triphosphorothioate sodium salt; Gtp-γ-S Na; GtpγS; Thio-GTP sodium salt
EINECS	Contact for details

Quality Control

Our Gtp-γ-S Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing specific results for purity, water content, and endotoxin levels is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Tested in functional enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.