Description

Nortriptyline Metabolite (+/-)-(Z) is a specific stereoisomeric metabolite of the tricyclic antidepressant nortriptyline, identified by CAS No. 37439-87-5. This compound is of critical importance for pharmaceutical research and development, serving as a key reference standard for analytical and metabolic studies. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) research, bioanalytical method development, and quality control testing.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the qualitative and quantitative analysis of nortriptyline and its metabolites in biological matrices.
• Drug Metabolism Studies: Essential for investigating the metabolic pathways, pharmacokinetics, and bioavailability of nortriptyline in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a critical standard for developing and validating LC-MS/MS, HPLC, and GC methods in compliance with FDA, EMA, and ICH guidelines.
• Pharmacology Research: Utilized in studies to understand the activity, toxicity, and disposition of nortriptyline metabolites.
• Quality Control & Assurance: Employed in pharmaceutical QC labs to ensure the specificity and accuracy of assays for drug substances and products.
• Forensic Toxicology: Acts as a reference compound in forensic analyses for the detection and confirmation of nortriptyline use.

Basic Information

Product Name	Nortriptyline Metabolite (+/-)-(Z)
CAS No.	37439-87-5
Molecular Formula	C19H21NO
Molecular Weight	279.38 g/mol
Synonyms	10,11-Dihydro-10-hydroxy nortriptyline (Z-isomer); (Z)-10-Hydroxynortriptyline; 10-Hydroxynortriptyline (cis-isomer); Nortriptyline Hydroxymetabolite; E-10-hydroxynortriptyline (related isomer); PNU-28693 (potential research code); 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, 10-hydroxy-; Nortriptyline metabolite E (obsolete nomenclature).
EINECS	Contact for details

Quality Control

Our Nortriptyline Metabolite (+/-)-(Z) is manufactured under strict quality systems suitable for research and analytical applications. Each batch undergoes rigorous identity confirmation, purity analysis, and impurity profiling using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing lot-specific results for assay, related substances, and residual solvents are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.