Description

Chondroitin 6-Sulfotransferase CAS NO 37292-93-6 is a critical enzyme responsible for the sulfation of chondroitin at the 6-O position, a key modification in the biosynthesis of chondroitin sulfate proteoglycans. This precise enzymatic activity is essential for producing structurally defined glycosaminoglycans (GAGs) with specific biological functions. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors for applications in drug discovery, glycobiology studies, and the synthesis of bioactive compounds.

Application

• Glycobiology and Biochemistry Research: Used as a key tool enzyme to study the biosynthesis, structure, and function of chondroitin sulfate and other glycosaminoglycans.
• Drug Discovery & Development: Employed in the enzymatic synthesis of defined chondroitin sulfate oligosaccharides for screening as potential therapeutic agents targeting inflammation, cancer, and neurological disorders.
• Biocatalysis for Fine Chemicals: Utilized in the in-vitro production of specific sulfated carbohydrate structures that are difficult to synthesize by chemical methods alone.
• Diagnostic Reagent Manufacturing: Serves as a component in enzymatic assay kits designed to analyze sulfotransferase activity or quantify specific GAG structures in biological samples.
• Tissue Engineering and Regenerative Medicine: Applied to modify biomaterial surfaces with specific sulfated GAG patterns to control cell behavior, differentiation, and tissue regeneration.
• Enzyme Characterization Studies: Acts as a standard or subject in studies aimed at understanding sulfotransferase kinetics, inhibition, and structure-activity relationships.

Basic Information

Product Name	Chondroitin 6-Sulfotransferase
CAS No.	37292-93-6
Molecular Formula	Information available upon request.
Molecular Weight	Information available upon request.
Synonyms	Chondroitin 6-O-sulfotransferase; C6ST; C6ST-1; CHST3; Carbohydrate sulfotransferase 3; Galactosaminyl 4-sulfate 6-O-sulfotransferase; Chondroitin sulfotransferase; UDP-N-acetylgalactosamine:chondroitin sulfate 6-sulfotransferase
EINECS	Contact for details

Quality Control

Our Chondroitin 6-Sulfotransferase is produced and handled under stringent conditions to ensure high activity, purity, and batch-to-batch consistency. Each lot is subjected to rigorous analytical testing, including activity assays and purity assessments. A comprehensive Certificate of Analysis (COA) detailing specific activity, protein content, purity, and storage buffer composition is provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after use to prevent moisture absorption. Store in a dedicated freezer for biochemicals.

Specification

Item	Specification
Appearance	Clear to slightly opalescent solution
Specific Activity	≥ [Value] units/mg protein
Protein Concentration	≥ [Value] mg/mL (Bradford assay)
Purity (SDS-PAGE)	≥ 90%
Buffer Composition	Tris-HCl, Glycerol, DTT (or similar stabilizers)
pH	7.0 - 8.0
Endotoxin Level	< 1.0 EU/μg (for research-grade)
Biological Activity	Confirmed by in-vitro sulfation assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.