Description

Progesterone Monooxygenase F. Cylindro-C Apron R., ~0.6 U/G is a highly purified enzyme preparation derived from a specific fungal source, designed for the selective hydroxylation of steroid substrates. This biocatalyst is critical for enabling efficient, stereospecific synthesis pathways in advanced pharmaceutical manufacturing and fine chemical research. It is an essential tool for R&D laboratories and production facilities specializing in steroid hormone synthesis, drug metabolite production, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate Synthesis: Key biocatalyst for the stereoselective hydroxylation of progesterone and related steroid backbones in the production of active pharmaceutical ingredients (APIs).
• Drug Metabolite Production: Used in vitro to generate human-relevant metabolites of steroid-based drugs for pharmacological and toxicological studies.
• Fine Chemical Manufacturing: Enables green chemistry routes for the synthesis of complex steroid derivatives used in agrochemicals and high-value materials.
• Biocatalysis Research & Development: Serves as a model enzyme in academic and industrial research for studying cytochrome P450 monooxygenase mechanisms and engineering.
• Diagnostic Reagent Formulation: A component in enzymatic assay kits for the detection and quantification of specific steroid compounds.
• Process Development & Scale-Up: Employed in developing and optimizing scalable, enzymatic manufacturing processes for steroid transformations.

Basic Information

Product Name	Progesterone Monooxygenase F. Cylindro-C Apron R., ~0.6 U/G
CAS No.	37256-85-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Progesterone Monooxygenase; Steroid 11-α-Hydroxylase; P45011α; Cytochrome P450 11α-hydroxylase; 11α-Hydroxylase; Progesterone, reduced-adrenal-iron protein oxidoreductase (11α-hydroxylating); EC 1.14.15.4; Apron R. Enzyme
EINECS	Contact for details

Quality Control

Our enzyme products are manufactured and tested under strict quality management protocols to ensure batch-to-batch consistency and performance reliability. Each lot is characterized for specific activity, protein content, and purity profile. Certificates of Analysis (COA) documenting these parameters are provided with every shipment. While not a bulk chemical, production adheres to principles of GMP for enzymes used in research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or suspension
Specific Activity	~0.6 U/mg protein (Typical)
Protein Content (Bradford)	Reported on COA
Purity (SDS-PAGE)	≥ 90%
Identification (Activity)	Catalyzes 11α-hydroxylation of progesterone
Stability	≥ 90% activity retained after 12 months at -20°C
Microbial Limits	Absence of specified pathogens

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.